Single-cell sequencing and bioinformatic tools applications discussed in Research Review

Nowadays, single-cell RNA sequencing technologies and related bioinformatics tools are emerging as essential devices for dissecting tumors at single-cell resolution and understanding carcinogenesis and drug response mechanisms, representing a turning point in cancer research. The most significant outcomes have been collected and discussed in the review “Single-cell RNA sequencing and bioinformatics as tools to decipher … Continue reading Single-cell sequencing and bioinformatic tools applications discussed in Research Review

Tumor Blood Vessel Growth May Be Target to Treat Glioblastoma and Other Cancers

Figure 1. TMEM230 promotes aggressive tumor behavior in a human cell line model of GBM. Down regulation of TMEM230 resulted both in fewer tumor cells and less vascularization 3D tissue models Figure 2 TMEM230 promotes vascular mimicry by inducing cancer cells to generate vessel like structures. A novel protein regulator of tumor angiogenesis, TMEM230, was … Continue reading Tumor Blood Vessel Growth May Be Target to Treat Glioblastoma and Other Cancers

SHRO’s Giordano Meets with Appropriations Committee Chair on Capitol Hill

Congresswoman Rosa DeLauro (D-CT), Chair of the House Appropriations Committee meets with Dr. Antonio Giordano in Washington. WASHINGTON, D.C. November 4, 2021 – Professor Antonio Giordano, M.D., Ph.D., Neapolitan Oncologist, Director of the Sbarro Institute for Cancer Research at Temple University and founder of the Sbarro Health Research Organization (SHRO), met today with Congresswoman Rosa DeLauro … Continue reading SHRO’s Giordano Meets with Appropriations Committee Chair on Capitol Hill

Research Supports More Effective Choices Than Ever for Drug-Free Pain Relief During Labor and Delivery

Researchers coordinated by Professor Antonio Giordano, M.D., Ph.D., Founder and Director of the Sbarro Health Research Organization (SHRO) have highlighted the effectiveness of non-pharmacological analgesic techniques during childbirth in a review recently published in the journal Eukaryotic Gene Expression. “The search for alternative analgesic techniques is a promising and exciting research field,” comments the first author, … Continue reading Research Supports More Effective Choices Than Ever for Drug-Free Pain Relief During Labor and Delivery

Elucidation of Novel mechanisms regulating the tumor suppressor RBL1/p107 levels in mesothelioma and lung cancer cells

Research Alert The retinoblastoma-like (RBL)1/p107 protein is a member of the retinoblastoma (RB) family including the retinoblastoma (RB)1/p105 protein and RBL2/p130. They are key regulators of the cell cycle and play a central role in modulating cell proliferation.  RB proteins act as tumor suppressors and their dysregulation is associated with tumor initiation. However, the mechanisms … Continue reading Elucidation of Novel mechanisms regulating the tumor suppressor RBL1/p107 levels in mesothelioma and lung cancer cells

Fungal and Bacterial Biodeterioration of Outdoor Canvas Paintings: The Case of the Cloisters of Quito, Ecuador

A multidisciplinary work of international range for new studies in the biodeterioration of canvas paintings he journal Critical Review In Eukaryotic Gene Expression has just published an interesting article entitled: “Fungal And Bacterial Biodeterioration Of Outdoor Canvas Paintings: The Case Of The Cloisters Of Quito, Ecuador.” The document is available for all the scientific and academic community … Continue reading Fungal and Bacterial Biodeterioration of Outdoor Canvas Paintings: The Case of the Cloisters of Quito, Ecuador

GYNOCARE COST Creates International Research Collab on Rare Cancers Affecting Millions of Women Annually

Sbarro Health Research Organization (SHRO) Founder and Director, Antonio Giordano, M.D., Ph.D., of Temple University and the University of Siena, Italy, is part of the GYNOCARE COST Action (CA18117) chaired by Prof Jean Calleja Agius of the University of Malta. This COST Action has just launched the official website: www.gynocare.net.  GYNOCARE is a European network for … Continue reading GYNOCARE COST Creates International Research Collab on Rare Cancers Affecting Millions of Women Annually

An Emerging Clue to Cancer Therapy: Radiotherapy-Induced Autophagy May Enhance Modulation of Cell Cycle

Building on prior success combining Cyclin-Dependent Kinase (CDK) inhibitors with hormone therapy to treat breast cancer, researchers are now exploring the potential integration of CDK inhibitors with radiotherapy in a paper issued in the International Journal of Molecular Sciences. The paper was authored by an international team led by the Sbarro Health Research Organization (SHRO), Temple University, … Continue reading An Emerging Clue to Cancer Therapy: Radiotherapy-Induced Autophagy May Enhance Modulation of Cell Cycle

Human-Dog Relationship during the First COVID-19 Lockdown in Italy

The isolation and abrupt interruption of social contacts and interpersonal affective relationships caused by the Covid-19 pandemic have triggered greater fragility and uncertainty in people and this condition has also had repercussions in the human-dog relationship. The paper "Human-Dog Relationship during the First COVID-19 Lockdown in Italy" published in the prestigious international journal "Animals" is … Continue reading Human-Dog Relationship during the First COVID-19 Lockdown in Italy

Researchers Investigate Link between LncRNA MORT (ZNF667-AS1) and Gynecological Cancer

Long non‑coding RNAs (lncRNAs) play a critical role in tumorigenesis. LncRNAs can beclassified into tumor suppressor genes or oncogenes, depending on their function within the cellular context and the signalling pathways in which they are involved. These regulatory RNAs are potential therapeutic targets for cancer due to their tissue and tumor specificity. The lncRNA Mortal Obligate … Continue reading Researchers Investigate Link between LncRNA MORT (ZNF667-AS1) and Gynecological Cancer