Targeting Receptor EphA2 Reduces Bladder Cancer Tumor Growth and Increases Chemotherapy Effectiveness

An international team of investigators has recently discovered that the receptor tyrosine-kinase EphA2 activated by the growth factor progranulin is a tumorigenic driver of bladder cancer progression. The study, “Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer,” has been recently published in the international-peer-reviewed journal Matrix Biology. The paper describes how EphA2 depletion severely blunted … Continue reading Targeting Receptor EphA2 Reduces Bladder Cancer Tumor Growth and Increases Chemotherapy Effectiveness

‘Genetic Shield’ May Explain Lower COVID Mortality in Southern Italy Compared to North

“A 'genetic shield' may have protected southern Italy from the Sars-CoV-2 tsunami that swept the northern regions,” says Antonio Giordano, M.D., Ph.D., Founder and Director of the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University, and Professor of Pathology at the University of Siena, Italy. “The hypothesis needs to be studied before … Continue reading ‘Genetic Shield’ May Explain Lower COVID Mortality in Southern Italy Compared to North

Genetics May Explain High COVID-19 Mortality in Italy, Inform Global Pandemic Response

Newswise — On March 11th 2020 the World Health Organization declared Coronavirus disease (COVID-19) a pandemic. In a few weeks the infection spread across the globe causing hundreds of thousands of deaths worldwide. Italy was the first European country to be hard-hit by the infection and among the countries with a higher mortality rate. During … Continue reading Genetics May Explain High COVID-19 Mortality in Italy, Inform Global Pandemic Response

Dr. Giordano Featured in Forbes Article on COVID-19 Antibody Tests in Italy and USA

The article in Forbes discusses how the USA can learn from Italy, and their antibody testing during the Italy re-opening phase.  There are many companies, international and local, which are racing to win the largest share of the COVID-19 antibody testing market in Italy. WHO warns that antibody tests may not be of great value, … Continue reading Dr. Giordano Featured in Forbes Article on COVID-19 Antibody Tests in Italy and USA

Coronavirus, Antonio Giordano: “There is no connection with climate change”

The director of the Sbarro Institute in Philadelphia explains what COVID-19 is and how to contain the infection but underlines: "Pollution is a worse threat to our health" n the last few days we have witnessed panic scenes due to the spread of the coronavirus: escapes from the red zone, supermarkets taken by storm to stock … Continue reading Coronavirus, Antonio Giordano: “There is no connection with climate change”

Understanding COVID-19 Origins First Step to Treating Cases, Stopping Spread

“The new virus originating from Wuhan is the third coronavirus that has made the ‘jump’ from animals to humans,” explains Enrico Bucci, Ph.D., professor and research scientist at the Sbarro Health Research Organization (SHRO), at Temple University in Philadelphia. “We witnessed SARS, which infected 8,000 people between 2002 and 2003 and killed 775; and then … Continue reading Understanding COVID-19 Origins First Step to Treating Cases, Stopping Spread

Coronavirus: concern and precaution ok, but panic and hysteria unjustified, says expert

Founder and Director of the Sbarro Health Research Organization (SHRO), Antonio Giordano, M.D., Ph.D., is uniquely qualified to comment on the current COVID-19 outbreak caused by the novel coronavirus known as SARS-CoV-2. A former physician turned research scientist, Giordano collaborates with scientists working in both the United States and Italy through projects with SHRO, Temple … Continue reading Coronavirus: concern and precaution ok, but panic and hysteria unjustified, says expert

Link Found Between Bladder Cancer and Collagen Receptor, Revealing Possible Treatment Target

A team of investigators has recently discovered that the collagen receptor DDR1 functionally interacts with the insulin-like growth factor system in regulating bladder cancer. The study entitled “Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer” has been recently accepted in the international-peer-reviewed journal Matrix Biology Plus. This work is an international … Continue reading Link Found Between Bladder Cancer and Collagen Receptor, Revealing Possible Treatment Target