Single-cell sequencing and bioinformatic tools applications discussed in Research Review

Nowadays, single-cell RNA sequencing technologies and related bioinformatics tools are emerging as essential devices for dissecting tumors at single-cell resolution and understanding carcinogenesis and drug response mechanisms, representing a turning point in cancer research. The most significant outcomes have been collected and discussed in the review “Single-cell RNA sequencing and bioinformatics as tools to decipher … Continue reading Single-cell sequencing and bioinformatic tools applications discussed in Research Review

Tumor Blood Vessel Growth May Be Target to Treat Glioblastoma and Other Cancers

Figure 1. TMEM230 promotes aggressive tumor behavior in a human cell line model of GBM. Down regulation of TMEM230 resulted both in fewer tumor cells and less vascularization 3D tissue models Figure 2 TMEM230 promotes vascular mimicry by inducing cancer cells to generate vessel like structures. A novel protein regulator of tumor angiogenesis, TMEM230, was … Continue reading Tumor Blood Vessel Growth May Be Target to Treat Glioblastoma and Other Cancers

Research Supports More Effective Choices Than Ever for Drug-Free Pain Relief During Labor and Delivery

Researchers coordinated by Professor Antonio Giordano, M.D., Ph.D., Founder and Director of the Sbarro Health Research Organization (SHRO) have highlighted the effectiveness of non-pharmacological analgesic techniques during childbirth in a review recently published in the journal Eukaryotic Gene Expression. “The search for alternative analgesic techniques is a promising and exciting research field,” comments the first author, … Continue reading Research Supports More Effective Choices Than Ever for Drug-Free Pain Relief During Labor and Delivery

Elucidation of Novel mechanisms regulating the tumor suppressor RBL1/p107 levels in mesothelioma and lung cancer cells

Research Alert The retinoblastoma-like (RBL)1/p107 protein is a member of the retinoblastoma (RB) family including the retinoblastoma (RB)1/p105 protein and RBL2/p130. They are key regulators of the cell cycle and play a central role in modulating cell proliferation.  RB proteins act as tumor suppressors and their dysregulation is associated with tumor initiation. However, the mechanisms … Continue reading Elucidation of Novel mechanisms regulating the tumor suppressor RBL1/p107 levels in mesothelioma and lung cancer cells

Fungal and Bacterial Biodeterioration of Outdoor Canvas Paintings: The Case of the Cloisters of Quito, Ecuador

A multidisciplinary work of international range for new studies in the biodeterioration of canvas paintings he journal Critical Review In Eukaryotic Gene Expression has just published an interesting article entitled: “Fungal And Bacterial Biodeterioration Of Outdoor Canvas Paintings: The Case Of The Cloisters Of Quito, Ecuador.” The document is available for all the scientific and academic community … Continue reading Fungal and Bacterial Biodeterioration of Outdoor Canvas Paintings: The Case of the Cloisters of Quito, Ecuador

An Emerging Clue to Cancer Therapy: Radiotherapy-Induced Autophagy May Enhance Modulation of Cell Cycle

Building on prior success combining Cyclin-Dependent Kinase (CDK) inhibitors with hormone therapy to treat breast cancer, researchers are now exploring the potential integration of CDK inhibitors with radiotherapy in a paper issued in the International Journal of Molecular Sciences. The paper was authored by an international team led by the Sbarro Health Research Organization (SHRO), Temple University, … Continue reading An Emerging Clue to Cancer Therapy: Radiotherapy-Induced Autophagy May Enhance Modulation of Cell Cycle

The Medicine in Eye Drops Needs a Disguise to Sneak Past Your Tears

Scientists use engineered protein coating that binds to receptors on the surface of corneal cells to improve drug uptake. The most practical solution for drug delivery to the eyeball is topical, i.e. eye drops. However, a naturally occurring substance in tears actually can interact with the drug delivery system (DDS), hindering absorption of the drug … Continue reading The Medicine in Eye Drops Needs a Disguise to Sneak Past Your Tears

Inflammation and Procalcitonin Predict Success, or Not, of Lung Cancer Treatment

In patients with non-small cell Lung Cancer (NSCLC), the presence of either high chronic inflammation, or procalcitonin levels in the blood as a response to bacterial infection, both predict a poor response to treatment with immune checkpoint blockade.  The novel treatment studied includes peripheral-immune-checkpoint blockade (P-ICB) with mAbs to PD-1 (nivolumab and pembrolizumab), or PD-L1 … Continue reading Inflammation and Procalcitonin Predict Success, or Not, of Lung Cancer Treatment

Researchers Call for More Transparency from Russia’s Sputnik COVID Vaccine

“It is not a problem connected to “the Sputnik V” vaccine itself,” argues Prof. Enrico Bucci, adjunct professor in the Department of Biology, Temple University, and senior staff member of the Sbarro Health Research Organization (SHRO). “It is a problem connected to the way results are documented, data are provided, and scientific journals react to … Continue reading Researchers Call for More Transparency from Russia’s Sputnik COVID Vaccine

Like Asbestos, Do Carbon Nanotubes Have Potential Health Risks?

 A new study examines the recent literature on carbon nanotubes toxicity highlighting their strong inflammatory potential for the respiratory system. The Carbon nanotubes are the most promising type of nano-materials used in the field of nanotechnology for applications in medicine, sporting goods, automotive parts and water filters, among others. The similarities in physico-chemical characteristics between … Continue reading Like Asbestos, Do Carbon Nanotubes Have Potential Health Risks?