Hijacking cancer cells with a virus while blocking cells’ antiviral defenses could knock out mesothelioma

Malignant pleural mesothelioma (MPM) is a very aggressive cancer mainly caused by exposure to asbestos, against which no curative modalities exist, although many different strategies have been attempted so far. Research Alert A study exploring a new combination of therapeutic agents, dl922-947, an oncolytic adenovirus, and  AZD1775, an inhibitor of the DNA damage checkpoint kinase WEE1, … Continue reading Hijacking cancer cells with a virus while blocking cells’ antiviral defenses could knock out mesothelioma

Biomarker Candidates for Potential Early Diagnosis of Mesothelioma Reveal Mechanism of Tumor Escape from Immunosurveillance

Prof. Antonio Giordano with his collaborators from the National Cancer Institute of Naples, Pascale Foundation Mesothelioma is a deadly cancer mainly caused by exposure to asbestos fibers. Unfortunately, mesothelioma is generally diagnosed at an already advanced stage and none of the therapeutic strategies  tried so far is able to eradicate the disease. So new biomarkers … Continue reading Biomarker Candidates for Potential Early Diagnosis of Mesothelioma Reveal Mechanism of Tumor Escape from Immunosurveillance

Key Immune System Genes Identified to Explain High COVID Deaths and Spread in Northern Italy Versus Fewer Cases and Deaths in the South

Not long after the Coronavirus disease (Covid-19) outbreak in China, Italy was hard-hit by the infection and rapidly became one of the countries with the highest mortality rate. The disease was first detected on February 20 in Lombardy, a region in the Northern area, and rapidly spread throughout the country. The Southern regions and the … Continue reading Key Immune System Genes Identified to Explain High COVID Deaths and Spread in Northern Italy Versus Fewer Cases and Deaths in the South

Despite Promising Lab Results, Most Precision Medicine Therapies for Mesothelioma Fail in the Clinical Setting

Researchers discuss the case of SRC family kinase inhibitors pointing to new directions to tackle translational challenges Newswise — Malignant mesothelioma (MM) is a lethal cancer mainly caused by exposure to asbestos, for which, unfortunately, no current treatment has proven effective, despite the identification of several promising therapeutic targets over the years. SRC, the first … Continue reading Despite Promising Lab Results, Most Precision Medicine Therapies for Mesothelioma Fail in the Clinical Setting

Targeting Receptor EphA2 Reduces Bladder Cancer Tumor Growth and Increases Chemotherapy Effectiveness

An international team of investigators has recently discovered that the receptor tyrosine-kinase EphA2 activated by the growth factor progranulin is a tumorigenic driver of bladder cancer progression. The study, “Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer,” has been recently published in the international-peer-reviewed journal Matrix Biology. The paper describes how EphA2 depletion severely blunted … Continue reading Targeting Receptor EphA2 Reduces Bladder Cancer Tumor Growth and Increases Chemotherapy Effectiveness

‘Genetic Shield’ May Explain Lower COVID Mortality in Southern Italy Compared to North

“A 'genetic shield' may have protected southern Italy from the Sars-CoV-2 tsunami that swept the northern regions,” says Antonio Giordano, M.D., Ph.D., Founder and Director of the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University, and Professor of Pathology at the University of Siena, Italy. “The hypothesis needs to be studied before … Continue reading ‘Genetic Shield’ May Explain Lower COVID Mortality in Southern Italy Compared to North

Genetics May Explain High COVID-19 Mortality in Italy, Inform Global Pandemic Response

Newswise — On March 11th 2020 the World Health Organization declared Coronavirus disease (COVID-19) a pandemic. In a few weeks the infection spread across the globe causing hundreds of thousands of deaths worldwide. Italy was the first European country to be hard-hit by the infection and among the countries with a higher mortality rate. During … Continue reading Genetics May Explain High COVID-19 Mortality in Italy, Inform Global Pandemic Response

Link Found Between Bladder Cancer and Collagen Receptor, Revealing Possible Treatment Target

A team of investigators has recently discovered that the collagen receptor DDR1 functionally interacts with the insulin-like growth factor system in regulating bladder cancer. The study entitled “Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer” has been recently accepted in the international-peer-reviewed journal Matrix Biology Plus. This work is an international … Continue reading Link Found Between Bladder Cancer and Collagen Receptor, Revealing Possible Treatment Target

Researchers Find Potential New Target for Mesothelioma Treatment

by Tim Povtak    Research & Clinical Trials       Jan 14, 2020 An international research team has identified a novel molecular target with potential to significantly improve future treatment of malignant pleural mesothelioma. The recent findings could lead to a drug that targets key genetic inhibitors often preventing a patient’s own immune system from suppressing mesothelioma … Continue reading Researchers Find Potential New Target for Mesothelioma Treatment

Lower Survival in Patients with High BMI and HER2+ Metastatic Breast Cancer Treated with Pertuzumab and Trastuzumab

High BMI correlates to lower survival in patients with HER2+ metastatic breast cancer, even among patients showing initial positive response to new anti-HER2 agents pertuzumab and trastuzumab. An international team of researchers found that high BMI correlates to lower survival in patients with HER2+ metastatic breast cancer, even among patients showing initial positive response to … Continue reading Lower Survival in Patients with High BMI and HER2+ Metastatic Breast Cancer Treated with Pertuzumab and Trastuzumab